三个新大环草酰胺Ni(Ⅱ)配合物配体的合成、结构和DNA切割活性研究

合成了3个新的大环草酰胺Ni(Ⅱ)单核配合物NiL1(1),NiL2·CH3CH2OH(2)和NiL3·1.25H2O(3).由于羟基和草酰胺基团的氧原子都能够与金属离子配位,因此,NiL1-3可以用作构筑同多核和异多核配位化合物的配合物配体.X-射线单晶结构分析表明,每个大环配体的4个N原子与Ni(Ⅱ)配位,构成变形的平面正方形配位环境;Ni-N键的长度都非常短,表明3个大环配体中所有氮原子的配位能力都很强.1~3中的醇羟基使羟自由基淬灭,从而抑制了配合物切割DNA的活性.     

区域经济增长与创新和创业精神关系的研究——以河南省为例

以企业家精神代表创新和创业精神,用1996—2008年的统计数据实证分析了河南省和全国企业家的创新、创业精神与经济增长之间的关系,以及两者的动态趋势,得出创新、创业精神与区域经济增长之间存在很强的正相关关系,河南企业家的创新、创业精神与全国其他省分的企业家表现基本相同.在研究结论的基础上,为河南发展企业家精神提供了几条建议.     

浅谈工程索赔的程序

随着工程招、投标制度及业主、监理、施工单位管理章程的进一步健全,索赔工作也逐步步入正规,只要我们充分理解施工图纸、技术规范及业主、监理、施工单位签订约合同协议和各项往来性文件,在索赔工作中做到有理、有据,将会让更多的索赔得以成功.     

基于改进BP神经网络的库区渗漏量敏感性分析

进行库区帷幕防渗时，为确定合理帷幕范围、渗透系数、厚度和深度，确保帷幕防渗质量和提高经济效益，需要进行渗流量敏感性分析．基于传统BP神经网络，并采用批处理、动量滤波、可变学习速率和遗传算法对之改进，建立网格权重和标准化重要性的关系，确定4种防渗方案中各因素对渗漏量的敏感性大小．对比分析可知，方案4更为经济合理，此方案中影响渗漏量的主要因素为渗透系数，且增加帷幕深度比增加帷幕厚度更为经济有效．     

教育生态学视角下应用文教学探析

运用教育生态学理论,对目前应用文写作教学的现状加以分析,从提高对应用文写作课程的认识、确立地位、整合内容、建构新模式、转变教学方法、改变考核方式等几个方面的阐述,提出了相应的对策,探讨了高职院校应用文写作教学改革的思路和方法。     

Pedigree transmission disequilibrium test for quantitative traits in farm animals

General pedigrees are very common in farm animals,and the recent availability of large panels of SNPs in domestic species has given new momentum to the search for the mutations underlying variation in quantitative traits.In this paper,we proposed a new transmission disequilibrium test approach,called the pedigree transmission disequilibrium test,which deals with general pedigrees and quantitative traits in farm animals.Compared with the existing pedigree disequilibrium test (PDT) and general linear model-based method QTDT,our approach performed better with higher power and lower type I error,especially in scenarios where the quantitative trait locus (QTL) effect was small.We also investigated the application of our approach in selective genotyping design.Our simulation studies indicated that it was plausible to implement a selective genotyping strategy in the proposed pedigree transmission disequilibrium test.We found that our approach performed equally well or better when only some proportion of the individuals in the two tails were genotyped compared with its performance when all the individuals in the pedigree were genotyped.     

让小学生全员有效参与科学课外创新实践活动

小学生参与科学课外创新实践活动,既是教育改革的需要,又是科学教学的重要组成.由于教育和社会的种种原因,目前小学科学课外实践活动都局限于少数和部分学生参与,这对全体学生科学素质的培养极为不利.我们要采用各种措施,促进全体学生有效参与科学课外创新实践活动,为国家的未来培养更多的创新人才.     

移动扩散燃烧火焰的实验及数值模拟

在不同工况下对直线运动下的扩散燃烧火焰进行了实验,并运用Fluent软件进行数值模拟对比分析.结果表明:火源自身的运动对燃烧火焰影响较大,风速为0 m/s时,火焰向火源运动的相反方向倾斜,火焰偏角随火源速度的增加而增大,当火源速度为0.36、0.44、0.55 m/s时,火焰偏角分别为36°、47°和60°;相对速度相同时,风作用和车运动下火焰向同一方向偏转,但火焰形态差异明显;由于绝对静止比相对静止的火焰散热快,故绝对静止火焰的燃烧温度更低;与绝对静止工况下的火焰相比,相对静止下的火焰形态发生偏移,方向与火源运动方向相反,且燃烧温度更高.由于内在影响和火焰形态都截然不同,故移动扩散燃烧火焰不能用相对运动的概念来简单分析.     

The impact of warrants introduction: Sign effect or magnitude effect?

The data of warrants underlying stocks was selected for the sample period from August, 2005 to December, 2009. These data the authors collected did not include the announcement date of reform of non-tradable underlying shares, and was available from Shanghai and Shenzhen stock exchanges. The event study method is employed to test the magnitude effect based on the Wild bootstrap, which is performed on the abnormal return, the cumulative abnormal return, and the standardized cumulative abnormal return. Empirical results show no evidence of magnitude effect but sign effect after warrants introduction. The authors argue that this phenomenon is caused by the migration of radical agents from stock market to warrant market.     

Biosorption and biodegradation of polycyclic aromatic hydrocarbons by Phanerochaete chrysosporium in aqueous solution

Biosorption and biodegradation of phenanthrene and pyrene by live and heat-killed Phanerochaete chrysosporium are investigated to elucidate the bio-dissipation mechanisms of polycyclic aromatic hydrocarbons(PAHs) in aqueous solution and its regulating factors.The effects of nutrient conditions(carbon source and nitrogen source concentrations),the co-existing Cu 2+,and repeated-batch feed of PAHs on the biosorption and biodegradation are systematically studied.The removal of PAHs by dead bodies of P.chrysosporium is attributed to biosorption only,and the respective partition coefficients of phenanthrene and pyrene are 4040 and 17500 L/kg.Both biosorption and biodegradation contribute to the dissipation of PAHs by live P.chrysosporium in water.After a 3-d incubation,the removal percentage via biosorption are 19.71% and 52.21% for phenanthrene and pyrene,respectively.With the increase of the incubation time(3 40 d),biodegradation gradually increases from 20.40% to 60.62% for phenanthrene,and from 15.55% to 49.21% for pyrene.Correspondingly,the stored-PAHs in the fungal bodies decrease.Under the carbon-rich and nitrogen-limit nutrient conditions,the removal efficiency and biodegradation of phenanthrene and pyrene are significantly promoted,i.e.99.55% and 92.77% for phenanthrene,and 99.47% and 83.97% for pyrene after a 60-d incubation.This phenomenon is ascribed to enhanced-biosorption due to the increase of fungal biomass under carbon-rich condition,and to stimulated-biodegradation under nitrogen-limit condition.For the repeated-batch feed of phenanthrene,the pollutant is continuously removed by live P.chrysosporium,and the contribution of biodegradation is enhanced with the repeated cycles.After 3 cycles,the biodegradation percentage is up to 90% with each cycle of a 6-d incubation.